Randomized study of sertraline and low‐dose amitriptyline in patients with Parkinson's disease and depression: Effect on quality of life
Identifieur interne : 003226 ( Main/Exploration ); précédent : 003225; suivant : 003227Randomized study of sertraline and low‐dose amitriptyline in patients with Parkinson's disease and depression: Effect on quality of life
Auteurs : Angelo Antonini [Italie] ; Silvana Tesei [Italie] ; Anna Zecchinelli [Italie] ; Paolo Barone [Italie] ; Danilo De Gaspari [Italie] ; Margherita Canesi [Italie] ; Giorgio Sacilotto [Italie] ; Nicoletta Meucci [Italie] ; Claudio Mariani [Italie] ; Gianni Pezzoli [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-08.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Amitriptyline, Amitriptyline (therapeutic use), Antidepressive Agents (therapeutic use), Depression, Depression (etiology), Depression (prevention & control), Female, Human, Humans, Low dose, Male, Middle Aged, Nervous system diseases, Parkinson Disease (psychology), Parkinson disease, Parkinson's disease, Quality of Life, Quality of life, Serotonin Uptake Inhibitors (therapeutic use), Sertraline, Sertraline (therapeutic use), Single-Blind Method, amitriptyline, depression, sertraline.
- MESH :
- chemical , therapeutic use : Amitriptyline, Antidepressive Agents, Serotonin Uptake Inhibitors, Sertraline.
- etiology : Depression.
- prevention & control : Depression.
- psychology : Parkinson Disease.
- Female, Humans, Male, Middle Aged, Quality of Life, Single-Blind Method.
Abstract
We assessed the effect of 3‐month treatment of sertraline (50 mg) or low‐dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single‐blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS‐17) score. Completion rate was 75% for sertraline (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS‐17 score reduction ≥ 50%) was 83.3% for sertraline and 72.7% for amitriptyline. Sertraline but not amitriptyline treatment determined a significant benefit on quality of life (PDQ‐39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ‐39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self‐perception of motor function and further emphasizes the need for its treatment. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20895
Affiliations:
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Le document en format XML
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<term>Depression (etiology)</term>
<term>Depression (prevention & control)</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Low dose</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
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<front><div type="abstract" xml:lang="en">We assessed the effect of 3‐month treatment of sertraline (50 mg) or low‐dose amitriptyline (25 mg) on depression and quality of life in 31 patients with Parkinson's disease in a prospective single‐blind randomized study. Both drugs significantly reduced the Hamilton Depression Rating Scale (HDRS‐17) score. Completion rate was 75% for sertraline (12 of 16) and 73% for amitriptyline (11 of 15). Responder rate (HDRS‐17 score reduction ≥ 50%) was 83.3% for sertraline and 72.7% for amitriptyline. Sertraline but not amitriptyline treatment determined a significant benefit on quality of life (PDQ‐39 scale). We found no change in Unified Parkinson's Disease Rating Scale scores. However, the improvement in specific PDQ‐39 subscores (mobility, activities of daily living, and stigma) suggests that depression affects patient self‐perception of motor function and further emphasizes the need for its treatment. © 2006 Movement Disorder Society</div>
</front>
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<tree><country name="Italie"><region name="Lombardie"><name sortKey="Antonini, Angelo" sort="Antonini, Angelo" uniqKey="Antonini A" first="Angelo" last="Antonini">Angelo Antonini</name>
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<name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name>
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<name sortKey="Meucci, Nicoletta" sort="Meucci, Nicoletta" uniqKey="Meucci N" first="Nicoletta" last="Meucci">Nicoletta Meucci</name>
<name sortKey="Pezzoli, Gianni" sort="Pezzoli, Gianni" uniqKey="Pezzoli G" first="Gianni" last="Pezzoli">Gianni Pezzoli</name>
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<name sortKey="Zecchinelli, Anna" sort="Zecchinelli, Anna" uniqKey="Zecchinelli A" first="Anna" last="Zecchinelli">Anna Zecchinelli</name>
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